ICSI Center

Molecular Genetics Research Laboratory for Male Infertility / Advanced Micromanipulation Research Laboratory on Mammalian Gametes

 

Our field of interest is to device and execute research projects in reproductive biology. The main focus is on designing and carrying out research projects on the physiology of human gametes, spermatozoa, and oocytes in order to understand their maturation and interaction. Other fields of interest are the genetic basis responsible for spermatogenesis and to explore techniques for assessment of aneuploidy of eggs and sperm. Systematically device and organize follow-up studies to investigate the wellbeing of children born from assisted reproductive technologies (ART), IVF, ICSI, and those resulting from cryopreservation. Investigate methods to enhance the efficiency of cryopreservation procedures of human eggs.

 

TEAM

 

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Stephanie Cheung

Stephanie has been with CRM since 2013. She is involved in genetics-based research, including the Assessment of Sperm Aneuploidy on Embryo Implantation, as well as the Role of Paternal Age on Embryo Development through Meiotic Errors. She is also working on a previously unestablished, inexpensive method of gender pre-selection. More recently, however, she has been investigating the possibility of carrying out a complete molecular karyotype on individual sperm cells with the use of Next Generation Sequencing.


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Alessandra Parrella

Alessandra graduated with a Master's degree in Biology from Università degli Studi del Sannio in 2015. Her past research involved examining the relationship between obesity and infertility. She is currently involved in examining DNA fragmentation of sperm using the TUNEL assay for clinical and research usage. Additionally, she is working with stem cells to investigate the process of in vitro spermatogenesis. She is now taking steps to work with mice to further explore the development of in vivo spermatogenesis.


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Derek Keating

Derek graduated from Boston University in 2014, receiving his undergraduate degree in Biology. He is currently involved in using the TUNEL assay to examine the DNA fragmentation of sperm in fresh and surgically retrieved samples for clinical and research usage.

 


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Philip Xie

Philip graduated from Stony Brook University with a Bachelor degree in Biology specialized in molecular and cellular bioengineering. He is interested in cytological study of gamete maturation, as well as clinical application of biomedical devices and bioinstrumentation on ART procedures.


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June Wang

June joined the team in March 2018. She previously worked with immunocytochemical staining to map cell types in mouse tissue, and she is now training on the TUNEL assessment of sperm DNA fragmentation. She graduated from NYU in 2016 with majors in Biology and Psychology.


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Aysha Trout

Aysha graduated from New York University in 2017 with a major in Biology and minors in Psychology and Chemistry. She is currently on the research team studying the differentiation of stem cells into spermatozoa.


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Brianne Barker

Brianne graduated from Lehigh University in 2018 with a Bachelor of Science in Biology with a minor in Psychology. She is currently working with RNA sequencing on sperm samples and is interested in studying how CRISPR-Cas9 can be used to edit male germ cells to correct mutations leading to genetic diseases. 


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Sherina Lawrence

Sherina is a class of 2018 Rutgers University graduate. She majored in Microbiology and minored in Public Health. She is currently researching the relationship between the presence of leukocytes and its effects on semen parameters.