ICSI Center

Advanced Reproductive Biology and Genetics Laboratory

 

We are dedicated to implementing cutting-edge research in the realm of Reproductive Biology. Our primary emphasis lies in delving into the intricacies of human gametes, spermatozoa and oocytes, to gain profound insights into their maturation processes and intricate interplay. Beyond that, our investigation extends into understanding the genetic underpinnings of infertility, employing advanced CRISPR-Cas9 editing techniques.

A significant hallmark of our laboratory is our pioneering success in devising and implementing a groundbreaking gender selection method for spermatozoa prior to Intrauterine Insemination (IUI) and Intracytoplasmic Sperm Injection (ICSI).

American Society for Reproductive Medicine Annual Meeting 2020


Transfer of Diploid Somatic Cells Into Enucleated Oocytes to Induce Meiosis-Like Haploidization

Aysha Trout, Philip Xie, Robert Setton, Zev Rosenwaks, Gianpiero D. Palermo

ASRM 2020 donor cell poster FINAL AT.jpg

The Impact of Double-Stranded Sperm DNA Breaks on ICSI Outcome

Derek Keating, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

DK_comet%252Bicsi_SC-page-001.jpg

Evaluating the Ability of an Oocyte to Repair Fragmented Sperm Chromatin

Derek, Keating, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

DK_scf+maturity_sc-page-001.jpg

Identifying the Best Method of Retrieving Spermatozoa with the Highest Genomic Integrity

Danielle Tavares, Alessandra Parrella, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

DT_ASRM-10_9%2BFinal1_SC-page-001.jpg

The Use of Semipermeable Spheres Engulfed with Mouse Embryonic Stem Cells to Generate Male Germ Cells

Sherina Lawrence, Mounia Haddad, Philip Xie, , Zev Rosenwaks, Gianpiero D. Palermo

SL_Direct Spherification Poster R3_SC.jpg

Identifying the Gamete Responsible for ICSI Fertilization Failure

Stephanie Cheung, Philip Xie, Alessandra Parrella, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

p481 AGT poster_final (1)1024_1.jpg

The Effects of Germline Mutations on the Ability of Surgically Retrieved Spermatozoa from Azoospermic Men to Support Embryonic Development

Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo

p790_ICSI_NOA_OA_Final-page-001.jpg

A Promising Ligand and Microfluidics Sperm Sex Selection Method

Stephanie Cheung, Philip Xie, Alessandra Parrella, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

p110 Gender Selection_Final.jpg

Epigenetic Effect of Abstinence time on the Reproductive Potential of Infertile Men

Brianne Barker, Alessandra Parrella, Sherina Lawrence, Zev Rosenwaks, Gianpiero D. Palermo

Epigenetic effect of  -page-001.jpg

Targeted ICSI Treatment in Globozoospermic Men According to Sperm PLCZ Content

Alessandra Parrella, Danielle Tavares, Philip Xie, Stephanie Cheung, Brianne Barker, Zev Rosenwaks, Gianpiero D. Palermo

Final ASRM GLOBO AGT 2-page-001.jpg

Manufacturing Oocytes Through Somatic Cell Nuclear Transfer

Aysha Trout, Philip Xie, Robert Setton, Zev Rosenwaks, Gianpiero D. Palermo

AT oral-page-001.jpg

Male Neogametogenesis to Generate Fully Developed Preimplantation Embryos

Sherina Lawrence, Philip Xie, Mounia Haddad, Allison Petrini, Zev Rosenwaks, Gianpiero D. Palermo

SL oral-page-001.jpg

Structural and Genomic Characterization of Globozoospermic Men

Alessandra Parrella, Philip Xie, Stephanie Cheung, Danielle Tavares, Zev Rosenwaks, Gianpiero D. Palermo

Final Globo SA ASRM 2020-page-001.jpg

The Impact of Spermatozoa Retrieved from Different Regions of the Epididymis on Reproductive Outcomes

Alessandra Parrella, June Wang, Danielle Tavares, Mounia Haddad, Zev Rosenwaks, Gianpiero D. Palermo

Final Poster Epididimys -page-001.jpg

A Novel Method to Attenuate Embryo Aneuploidy Due to Paternal Inheritance

Alessandra Parrella, Danielle Tavares, June Wang, Mounia Haddad, Derek Keating, Zev Rosenwaks, Gianpiero D. Palermo

Final Poster MFSS and PGT-page-001.jpg

Using Gene Expression Profiles of Ejaculates of NOA Men to Help Predict Successful Testicular Sperm Retrieval

Brianne Barker, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

Final Poster RNA pdf-page-001.jpg

Development of a Novel Technique to Edit the Genome of the Male Gamete

June Wang, Philip Xie, Zev Rosenwaks, Gianpiero D. Palermo

AT oral-page-001.jpg

The Impact of High Sperm Chromatin Fragmentation on Intrauterine Insemination Outcome

Mounia Haddad, Derek Keating, Alessandra Parrella, Zev Rosenwaks, Gianpiero D. Palermo

ASRM 20 Abstract IUI tunel 6.jpg

Using Mirror Copies of Parental Genomes to Generate Developmentally Competent Embryos

Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

ASRM 2020 DSC_VF-page-001.jpg

The Embryonic Developmental Competence of Reconstructed Zygotes Using a Cloned Male Gamete

Philip Xie, Aysha Trout, Zev Rosenwaks, Gianpiero D. Palermo

SL oral-page-001.jpg

Embryology Lab-on-a-Chip: Automated Oocyte Denudation Microfluidic Device

Amir Mokhtare, Philip Xie, Alireza Abbaspourrad, Zev Rosenwaks, Gianpiero D. Palermo

PX Oral-page-001.jpg